ACROMEGALY AND PREGNANCY (review and own observations)




acromegaly, pregnancy, growth hormone, insulin-like growth factor, methods of the treatment


It is presented the review of the literature concerning diagnostics acromegaly during pregnancy, tactics of conducting pregnant women with acromegaly, consequences influence of high levels of growth hormone (GH) and insulin-like growth factor-1 (ILF-1) on the organism of mother and foetus, pregnancy on progressing adenoma of hypophysis and secretion GH and ILF-1 and influences of various methods of the treatment on the organism of mother and foetus. There are situations of pregnancy in women with acromegaly of their own clinical practice.


Amar AP, Weiss MH. Neurosurg Clin North Amer 2003; 14:11–23.

Scheithauer BW, et al. Mayo Clin Proceed 1990; 65:461–474.

Gonzalez JG, et al. Amer J Med 1988; 85:217–220.

Aylamazyan EK, Novikov BN, Pavlova LP. Akusherstvo, Sankt-Peterburg, 2003:528 p.

Rigg LA, Lein A, Yen SS. Am J Obstetr Gynecol 1977; 129:454–456.

Molitch ME. Endocrinol Metabol Clin North Amer 2006; 35:99–116.

Caron Ph, et al. J Clin Endocrinol Metabol 2010; 95(10):4680–4687.

Arafah BM, Nasrallah MP. Endocrine-Related Cancer 2001; 8:287–305.

Unuane D, Tournaye H, Velkeniers B, Poppe K. Best Pract Res Clin Endocrinol Metabol 2011; 25(6):861-873.

Sauder SE, Frager M, Case GD, et al. J Clin Endocrinol Metabol 1984; 59:941–948.

Kaltsas GA, Androulakis II, Tziveriotis K, et al. Clin Endocrinol (Oxf.) 2007; 67:917–922.

Melmed S, Colao A, Barkan A, Molitch M, et al. J Clin Endocrinol Metabol 2009; 94(5):1509–1517.

Herman-Bonert V, Seliverstov M, Melmed S. J Clin Endocrinol Metabol 1998; 83:727–731.

Verhaeghe J. Gynecol Obstetr Invest 2008; 66:217–226.

Chang-DeMoranville BM, Jackson IM. Endocrinol Metabol Clin North Amer 1992; 21:649–668.

Hisano M, Sakata M, Watanabe N, et al. Arch Gynecol Obstetr 2006; 274:171–173.

Foyouzi N, Frisbaek Y, Norwitz ER. Obstetr Gynecol Clin North Amer 2004; 31:873–892.

Demura R, Odagiri E, Yoshimura M, et al. Acta Endocrinol 1982; 100: 114–119.

Shi QJ, Lei ZM, Rao CV, Lin J. Endocrinol 1993; 132(3):1387-1395.

Shmagel’ KV, Chreshnev VA. Akusherstvo Ginekologiya 2003; 3:9-12.

Chellakooty M, Vangsgaard K, Larsen T, et al. J Clin Endocrinol Metabol 2004; 89:384–391.

Lacroix MC, Guibourden J, Frendo JL, Muller F, Evain-Brion D. Placenta 2002; 23:S.87-94.

Scippo ML, Frankenne F, Hooghe-Peters EL et al. Mol Cell Endocrinol 1993; 92:R7-R13.

Fuglsang, J, Ovesen P. Growth Horm IGF Res 2006; 16(2):67-85.

Newbern, D, Freemark M. Curr Opin Endocrinol Diabetes Obes 2011; 18(6):409-416.

Beckers A, Stevenaert A, Foidart JM, et al. J Clin Endocrinol Metabol 1990; 71:725–731.

Gootwine E. Anim Reprod Sci 2004; 82-83:551-566.

Eriksson L, Frankenne F, Eden S. British J Obstetr Gynaecol 1989; 96:949–953.

Handwerger S, Freemark M. J Pediatr Endocrinol Metabol 2000; 13(4):343-356.

Clapp 3rd JF, Schmidt S, Paranjape A, Lopez B. Am J Obstet Gynecol 2004; 190:730–736.

Frohman LA. Endocrinologist 2001; 11:399-406.

Okada Y, Morimoto I, Ejima K, et al. Endocrinol J 1997; 44:117–120.

Yap AS, Clouston WM, Mortimer RH, Drake RF. Am J Obstet Gynecol 1990;163:477–478.

Whittaker PG, Stewart MO, Taylor A. Obstet Gynecol 1990; 76:223–229.

Lau S. L, McGrath S, Evain-Brion D, Smith R. J Endocrinol Invest 2008; 31:255–261.

Montini M, Pagani G, Gianola D, et al. J Endocrinol Invest 1990; 13:193.

Mikhail N. Mayo Clin. Proc 2002; 77:297–298.

De Menis E, Billeci D, Marton E, Gussoni G. J Clin Endocrinol Metabol 1999; 84:1489.

Brian SR, Bidlingmaier M, Wajnrajch MP, et al. J Clin Endocrinol Metabol 2007; 92(9):3374-3377.

Jaspers C, Haase R, Pfingsten H, et al. Clinical Invest 1993; 71:547–551.

Yap AS, Clouston WM, Mortimer RH, Drake RF. Am J Obstet Gynecol 1990; 163:477–478.

Newman CB. Endocrinol Metabol Clin N Amer 1999; 28:171–190.

Yap AS, Clouston WM, Mortimer RH, Drake RF. Amer J Obstetr Gynecol 1990; 163:477–478.

Liu CJ, Tyrrell B. Pituitary 2001; 4(3):179-185.

Banerjee A, Wynne K, Tan T, et al. Clin Endocrinol (Oxf.) 2009; 70(5):812-813.

Laloi-Michelin M, Ciraru-Vigneron N, Meas T. Int J Gynaecol Obstet 2007; 99(1):61-62.

Sandret L, Maison P, Chanson P. J Clin Endocrinol Metabol 2011; 96(5):1327-35.

Boulanger C, Vezzosi D, Bennet A, et al. J Endocrinol Invest 2004; 27:465–470.

Blackhurst G, Strachan MW, Collie D, et al. Clin Endocrinol 2002; 57:401–404.

Fassnacht M, Capeller B, Arlt W, et al. Clin Endocrinol 2001; 55:411–415.




How to Cite

Mykytyuk, M. (2013). ACROMEGALY AND PREGNANCY (review and own observations). Problems of Endocrine Pathology, 43(1), 75-82.

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