VITAMIN D-DEFICIENT STATES IN WOMEN WITH CARBOHYDRATE METABOLISM DISORDERS AND HEART FAILURE WITH PRESERVED EJECTION FRACTION
DOI:
https://doi.org/10.21856/j-PEP.2025.1.02Keywords:
prediabetes, type 2 diabetes mellitus, vitamin D insufficiency/deficiency, female gender, heart failure with preserved ejection fractionAbstract
Background. Despite the large-scale scientific discussions on the impact of vitamin D on comorbidities, it is undoubtedly important to study the potential impact of vitamin D deficiency on the onset of heart failure (HF) in combination with carbohydrate metabolism disorders. The aim of the study was to investigate the level of 25(OH)D in women with heart failure with preserved ejection fraction and prediabetes/type 2 diabetes; to assess the impact of vitamin D-deficient states on carbohydrate metabolism compensation and manifestations of heart failure.
Materials and methods. The prospective study involved 50 women with heart failure with preserved ejection fraction (HFpEF), who were divided into two study groups: Group I – 25 patients with prediabetes; Group II – 25 women with type 2 diabetes. Diagnosis of the body's vitamin D supply was carried out using the 25(OH)D indicator.
Results. Vitamin D-deficient states were confirmed in all patients: vitamin D deficiency was diagnosed in 44.0% of women in group I and 36.0% of women in group II, respectively; the frequency of vitamin D deficiency in women with type 2 diabetes was 64.0%, and in women with prediabetes – 56.0%. The results of the regression analysis indicate that an increase in glycated hemoglobin (HbA1C) is associated with vitamin D deficiency (group I: OR=2.162; 95% CI: 1.904-2.348; p=0.01; group II: OR=2.857; 95% CI: 1.341-5.097; р=0.031). In women with prediabetes and vitamin D deficiency, there was an increase in the level of the N-terminal pro В-type natriuretic peptide (NT-pro-BNP) (OR=1.049; 95% CI: 1.005-1.094; p=0.027) and changes in some echocardiographic parameters.
Conclusions. In women with prediabetes, vitamin D deficiency should be considered an early marker of carbohydrate metabolism decompensation and the course of heart failure. Adequate vitamin D levels affect the maintenance of cardiac function in patients with heart failure with preserved ejection fraction and impaired carbohydrate metabolism.
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