ВПЛИВ КОРЕКЦІЇ МІКРОБІОМУ КИШКІВНИКА НА ГІПЕРАМОНІЄМІЮ У ХВОРИХ НА ЦУКРОВИЙ ДІАБЕТ 2 ТИПУ

Nadija Zherdova; Tetiana Falalyeyeva; Olena Stepura; Olena Baka; Yuliia Shvets; Yurii Penchuk; Iryna Kostitska; Svitlana Mazii; Kateryna Khorievina

doi:10.21856/j-PEP.2024.4.02

INFLUENCE OF GUT MICROBIOTA CORRECTION ON HYPERAMMONEMIA IN PATIENTS WITH TYPE 2 DIABETES

Authors

Zherdova N. M. Сenter for Innovative Medical Technologies of the NAS of Ukraine, Kyiv, Ukraine https://orcid.org/0000-0003-2716-8447
Falalyeyeva T. M. Educational and scientific center «Institute of biology and medicine», Kyiv, Ukraine https://orcid.org/0000-0002-4415-9676
Stepura O. A. Сenter for Innovative Medical Technologies of the NAS of Ukraine, Kyiv, Ukraine https://orcid.org/0000-0003-2445-9927
Baka O. M. Сenter for Innovative Medical Technologies of the NAS of Ukraine, Kyiv, Ukraine https://orcid.org/0000-0001-6512-2605
Shvets Yu. V. Educational and scientific center «Institute of biology and medicine», Kyiv, Ukraine https://orcid.org/0000-0002-6829-0820
Penchuk Y. M. Educational and scientific center «Institute of biology and medicine», Kyiv, Ukraine https://orcid.org/0000-0001-5646-7003
Kostitska I. O. Ivano-Frankivsk National Medical University, Ivano-Frankivsk, Ukraine https://orcid.org/0000-0003-4319-0986
Mazii S. I. Сenter for Innovative Medical Technologies of the NAS of Ukraine, Kyiv, Ukraine https://orcid.org/0000-0002-5862-1251
Khorievina K. M. Сenter for Innovative Medical Technologies of the NAS of Ukraine, Kyiv, Ukraine https://orcid.org/0000-0001-8842-7735

DOI:

https://doi.org/10.21856/j-PEP.2024.4.02

Keywords:

diabetes mellitus, hyperammonemia, intestinal microbiota, probiotics

Abstract

The article presents data on the condition of gut microbiota in patients with type 2 diabetes and hyperammonemia. The aim of the study was to study the condition of the gut microbiota in patients with type 2 diabetes with hyperammonemia and to evaluate the effect of a multi-strain probiotic on ammonia levels.

Materials and methods. 25 patients were included in the study, 18 of them with hyperammonemia (11 women and 7 men) and 7 without hyperammonemia (7 women). The average age of patients with hyperammonemia was 62.10 ± 1.80 years, HbA_1c level – 7.06 ± 0.23%, average ammonia level – 43.64 ± 1.77 µM. To correct the intestinal microbiota, patients with hyperammonemia received a complex probiotic (14 strains, a total of 2.0×10⁹ CFU of probiotic microorganisms) 2 times per day for 1 month.

Results. It was established that in patients with type 2 diabetes with hyperammonemia, intestinal dysbiosis was determined with a reduced number of representatives of the genera Lactobacillus and Bifidobacterium, and an increased content of Escherichia and Pseudomonas bacteria. After the probiotic treatment, the quantitative composition of the microbiota changed, namely, the number of Bifidobacterium spp., Lactobacillus spp., E. coli, Enterococcus spp. increased, and the presence of bacteria with urease activity decreased, resulting in a statistically significant reduction in ammonia levels by 7.0 µM and fasting blood glucose levels by 1.33 mM.

Conclusions. Adjunctive therapy with multi-strain probiotics improves the state of the gut microbiota in type 2 diabetes patients with hyperammonemia, significantly reducing ammonia levels and fasting glycemia.

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Published

2024-12-15

How to Cite

Zherdova, N., Falalyeyeva, T., Stepura, O., Baka, O., Shvets, Y., Penchuk, Y., … Khorievina, K. (2024). INFLUENCE OF GUT MICROBIOTA CORRECTION ON HYPERAMMONEMIA IN PATIENTS WITH TYPE 2 DIABETES. Problems of Endocrine Pathology, 81(4), 18–29. https://doi.org/10.21856/j-PEP.2024.4.02