THE RELATIONSHIP BETWEEN MILITARY INJURIES AND THE DEVELOPMENT OF DIABETES (LITERATURE REVIEW)
DOI:
https://doi.org/10.21856/j-PEP.2025.4.06Keywords:
injuries, military personnel, diabetes mellitus, reviewAbstract
The article examines and systematizes the existing knowledge on the potential link between combat-related injuries in service members and the subsequent development of diabetes mellitus (DM). The aim of the study is to comprehensively analyze the possible physiological and psychological mechanisms underlying this association, as well as to review the available statistical data and scientific research in this field.
A literature search was conducted using the databases Web of Science, Scopus, MedLine, etc.
The results of the analysis indicate that certain types of injuries, in particular those accompanied by significant physical and psychological stress, traumatic brain injuries, amputations, or chronic inflammatory processes, may create a favorable environment for increasing the risk of developing DM in service members. These conditions are capable of inducing complex neuroendocrine and metabolic changes that disrupt the regulation of blood glucose levels and lead to insulin resistance.
The authors emphasize the critical importance of timely identification of risk factors for DM in service members who have survived injuries. Regular medical examinations, including assessment of metabolic status and the presence of comorbidities, are necessary for early diagnosis and implementation of preventive measures. In addition, the promotion of a healthy lifestyle, including a balanced diet and sufficient physical activity, can play a significant role in reducing the likelihood of developing diabetes in this vulnerable population.
Thus, the article emphasizes the need for further research to better understand the pathogenetic mechanisms linking injuries and diabetes in military personnel, as well as to develop effective strategies for medical support and prevention of this disease among veterans. The knowledge gained will contribute to the optimization of medical care and improvement of the quality of life of military personnel after returning from the combat zone.
References
Bruzina AS, Raymond-Pope CJ, Murray KJ, et al. Open Access 2024;2. https://doi.org/10.1038/s44324-024-00006-5
Serhiyenko V, Sehin V, Pankiv V, Serhiyenko A. Int J Endocrinol 2024;20(1): 58-67. https://doi.org/10.22141/2224-0721.20.1.2024.1359
Yoo JE, Lee D, Kim B, et al. Front Endocrinol 2025;15: 1437860. https://doi.org/10.3389/fendo.2024.1437860
Atlas bojovoi' hirurgichnoi' travmy (dosvid antyterorystychnoi' operacii' / operacii' ob’jednanyh syl) / pid red. VI. Cymbaljuka, Harkiv, 2021: 385 p.
Atlas promenevoi' diagnostyky vognepal'nyh poranen' / pid red. VI. Cymbaljuka, Vinnycja, 2024: 472 p.
Nathan DM. Diabetes Care 2014;37: 9-16. https://doi.org/10.2337/dc13-2112
Likuvannja poranenyh z bojovymy ushkodzhennjamy zhyvota (za dosvidom ATO/OOS): monografija / za red. KV. Gumenjuka, IP. Homenka, IA. Lurina, et al., Herson, 2022: 194 p.
Seljukova NJu, Lurin IA, Bojko MO, et al. Endokrynologija 2024;30(2): 135-141, evailable at: https://endokrynologia.com.ua/index.php/journal/article/view/745/643
Cymbaljuk VI, Homenko IP, Lurin IA, et al. Patomorfoz vognepal'nyh ran m’jakyh tkanyn, Harkiv, 2018: 176 p.
Szablewski L. Int J Mol Sci 2025;26(2): 542. https://doi.org/10.3390/ijms26020542
Qu F, Shi Q, Wang Y, et al. Chin Med J 2022;135: 2294-2300. https://doi.org/10.1097/cm9.0000000000002073
Magliano DJ, Sacre JW, Harding JL, et al. Nat Rev Endocrinol 2020;16: 321-331. https://doi.org/10.1038/s41574-020-0334-z
Morigny P, Boucher J, Arner P, Langin D. Nat Rev Endocrinol 2021;17: 276-295. https://doi.org/10.1038/s41574-021-00471-8
Tseng HJ Chen WC, Kuo TF, et al. Cell Mol Life Sci 2023;80: 101. https://doi.org/10.1007/s00018-022-04677-5
Papachristoforou E, Lambadiari V, Maratou E, Makrilakis K. J Diabetes Res 2020;2020: 7489795. https://doi.org/10.1155/2020/7489795
An S, Li Y, Jia X, et al. J Biochem Mol Toxicol 2022;36: e22988. https://doi.org/10.1002/jbt.22988
Baumel-Alterzon S, Katz LS, Brill G, et al. Trends Endocrinol Metab 2021;32: 7-19. https://doi.org/10.1016/j.tem.2020.11.002
Song LL, Qu YQ, Tang YP, et al. Redox Biol 2023;61: 102637. https://doi.org/10.1016/j.redox.2023.102637
Gerber PA, Rutter GA. Antioxid Redox Signal 2017;26: 501-518. https://doi.org/10.1089/ars.2016.6755
Jiao W, Ji J, Li F, et al. Mol Med Rep 2019;19: 667-677. https://doi.org/10.3892/mmr.2018.9637
Ruegsegger GN, Creo AL, Cortes TM, et al. J Clin Invest 2018;128: 3671-3681. https://doi.org/10.1172/jci120843
Sun J, Huang X, Niu C, et al. Redox Biol 2021;39: 101811. https://doi.org/10.1016/j.redox.2020.101811
Brownlee M. Nature 2001;414: 813-820. https://doi.org/10.1038/414813a
Chen X, Xie N, Feng L, et al. Chinese Med J 2025;138(1): 15-27. https://doi.org/10.1097/CM9.0000000000003230
Pisoschi AM, Pop A, Iordache F, et al. Eur J Med Chem 2021;209: 112891. https://doi.org/10.1016/j.ejmech.2020.112891
Kasper SO, Castle SM, Daley BJ, et al. Shock 2006;26(5): 485-488. https://doi.org/10.1097/01.shk.0000230302.24258.9f
Scheen AJ. Drugs 2004;64(22): 2537-2565. https://doi.org/10.2165/00003495-200464220-00004
Bucher M, Ittner KP, Hobbhahn J, et al. Hypertension 2001;38(2): 177-182. https://doi.org/10.1161/01.hyp.38.2.177
Kasper SO, Phillips EE, Castle SM, et al. Shock 2011;35(1): 80-85. https://doi.org/10.1097/SHK.0b013e3181e762da
Lurin I, Seljukova N, Korenjeva Je, et al. Probl Endokryn Patologii' 2023;80(4): 66-76. https://doi.org/10.21856/j-PEP.2023.4.08
Granner DK, Wang JC, Yamamoto KR. Adv Exp Med Biol 2015;872: 3-31. https://doi.org/10.1007/978-1-4939-2895-8_1
Burke SJ, Karlstad MD, Collier JJ. Shock 2016;46(3): 230-238. https://doi.org/10.1097/SHK.0000000000000607
Lurin I, Horoshun Je, Seljukova N, et al. Mizhnar Endokrynol Zhurn 2024;20(5): 349-356. https://doi.org/10.22141/2224-0721.20.5.2024.1419
Michopoulos V, Aimee VA, Neigh G. Experim Neurol 2016;284: 220-229. https://doi.org/10.1016/j.expneurol.2016.05.038
Seliukova N, Lurin I, Boiko M, et al. Endokrynologia 2024;29(2): 135-141. https://doi.org/10.31793/1680-1466.2024.29-2.135
Rosmond R. Psychoneuroendocrinology 2005;30(1): 1-10. https://doi.org/10.1016/j.psyneuen.2004.05.007
Rosenbaum S, Stubbs B, Ward PB, et al. Metabolism 2015;64(8): 926-933. https://doi.org/10.1016/j.metabol.2015.04.009
Eckel RH, Alberti KG, Grundy SM, Zimmet PZ. The Lancet 2010;375(9710): 181-183. https://doi.org/10.1016/S0140-6736(09)61794-3
Pasquali R, Ambrosi B, Armanini D, et al. J Clin Endocrinol Metab 2002;87(1): 166-175. https://doi.org/10.1210/jcem.87.1.8158
Epel ES, McEwen B, Seeman T, et al. Psychosomatic Med 2000;62(5): 623-632. https://doi.org/10.1097/00006842-200009000-00005
Duclos M, Pereira PM, Barat P, et al. Obesity Res 2005;13(7): 1157-1166. https://doi.org/10.1038/oby.2005.137
Oroian BA, Ciobica A, Timofte D, et al. Oxidative Medicine and Cellular Longevity 2021;2021: 5599265. https://doi.org/10.1155/2021/5599265
Salas J, Wang W, Schnurr PP, et al. J Psychosom Res 2023;175: 111510. https://doi.org/10.1016/j.jpsychores.2023.111510
Scherrer JF, Salas J, Norman SB, et al. JAMA Psychiatry 2019;76(11): 1159-1166. https://doi.org/10.1001/jamapsychiatry.2019.2096
Seljukova N, Horoshun E, Makarov V, et al. Probl Endocrine Pathol 2025;82(1): 58-66. https://doi.org/10.21856/j-PEP.2025.1.07
Patas K, Baker DG, Chrousos GP, Agorastos A. Curr Neuropharmacol 2024;22(4):524-542. https://doi.org/10.2174/1570159X21666230807152051
Dong H, Sun Y, Nie L, et al. Signal Transduc Target Ther 2024;9(1): 38. https://doi.org/10.1038/s41392-024-01755-x
Black PH. Brain, Behavior, and Immunity 2003;17(5): 350-364. https://doi.org/10.1016/s0889-1591(03)00048-5
Srivastava A, Chandra A, Yadav A, et al. Clin Neurol Neurosurg 2022;222: 107419. https://doi.org/10.1016/j.clineuro.2022.107419
Ciryam P, Gerzanich V, Simard JM. J Neurotrauma 2023;40(21-22): 2249-2269. https://doi.org/10.1089/neu.2023.0135
Schneider HJ, Kreitschmann-Andermahr I, Ghigo E, et al. JAMA 2007;298(12): 1429-1438. https://doi.org/10.1001/jama.298.12.1429
Wilde L, Ruysscher C, Oostra K. J Rehabil Med Clin Commun 2025;8: 36827. https://doi.org/10.2340/jrm-cc.v8.36827
Lucke-Wold BP, Logsdon AF, Nguyen L, et al. Nutritional Neurosci 2018;21(2): 79-91. https://doi.org/10.1080/1028415X.2016.1236174
Shaik K, Rasmussen S, Rahme R, Karsy M. Surgeries 2025;6(2): 38. https://doi.org/10.3390/surgeries6020038
Tropf JG, Hoyt BW, Walsh SA, et al. J Bone Joint Surg 2023;105(23): 1867-1874. https://doi.org/10.2106/JBJS.22.01284
Stewart IJ, Poltavskiy E, Howard JT, et al. J Gen Intern Med 2021;36(3): 713-721. https://doi.org/10.1007/s11606-020-06195-1
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Copyright (c) 2025 Lurin I. A., Misiura K. V., Seliukova N. Yu., Tyzhnenko T. V., Khoroshun E. M., Makarov V. V., Nehoduiko V. V.

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