ABOUT THE MECHANISMS OF CARBOHYDRATE METABOLISM DESORDERS IN PATIENTS WITH ACROMEGALY
DOI:
https://doi.org/10.21856/j-PEP.2012.3.03Keywords:
acromegaly, growth hormone, insulin-like growth factor-1, prolactin, diabetes mellitus, insulin-resistance, hyperinsulinemyAbstract
Investigation of the carbohydrate methabolism was done in 97 patients with active acromegaly
including 21 de novo acromegaly patients. Effects of growth hormone, insulin-like growth factor-1 and
prolactin on sensitivity to insulin and β-sell function were determined due to analysis of associations
of those hormones with insulin and HOMA indices. The role of permanent hypersomatotropinemy in
the pathogenesis of insulin-resistance and compensatory hyperinsulinemy in patients with acromegaly
was discussed.
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