CHARACTERISTICS OF CHANGES IN BLOOD LEPTIN IN CERTAIN VARIANTS OF INFERTILITY IN MEN
DOI:
https://doi.org/10.21856/j-PEP.2024.1.04Keywords:
male infertility, leptin, hyperleptinemia, androgen deficiency, body mass index, endocrinologyAbstract
Infertility is a vital medical and social problem nowadays. The male factor of infertility among married couples constitutes approximately 50%. One of the factors of the male infertility development is obesity, which is accompanied by an increase in the hormone of adipose tissue, leptin. It is the hyperleptinemia that is a predictor of the pathospermia formation.
Materials and Methods. A comprehensive clinical and laboratory examination of 130 young men with infertility was completed. 41 men were diagnosed with idiopathic pathospermia, 46 with infertility due to liver dysfunction, and 33 with post-traumatic encephalopathy. Body mass index, spermogram parameters were determined for all of the men, and a hormonal examination was performed. It included determination of testosterone, estradiol, luteinizing, follicle-stimulating hormones, and leptin rates in blood serum.
The results show that excess body weight is a risk factor for spermatogenesis disorders. It was determined that an increase in body weight and obesity is associated with an increase in leptin rates regardless of the state of spermatogenesis. Hyperleptinemia is a predisposing factor for the androgen deficiency development, which is accompanied by the antioxidant sperm balance disorder and negatively affects the process of sperm cells maturation and their motility, accordingly.
Conclusions. Men with hyperleptinemia demonstrated decrease in the androgen-estrogen balance, which influences the formation of androgen deficiency.
It was proved that there is an increase in leptin rates among men with liver pathology, regardless of body weight, which is a predisposing factor for the pathospermia formation.
References
Agarwal A, Baskaran S, Parekh N, et al. Lancet 2021;397(10271): 319-333. http://doi.org/10.1016/S0140-6736(20)32667-2.
ElTaieb MA, Ali AM, Sedeek MH, et al. Egypt J Hospital Med 2020;81(5): 1970-1976.
Chaudhuri GR, Das A, Bandhu S, et al. Middle East Fertil Soc J 2022;27: 1-12. https://doi.org/10.1186/s43043-022-00099-2.
Ayad B, Omolaoye TS, Louw N, et al. Front Reprod Health 2022;4: 1-15. https://doi.org/10.3389/frph.2022.822257.
Wang X, Zhang X, Huet L, et al. Reprod Biol Endocrinol 2018;16: 1-11. http://doi.org/10.1186/s12958-018-0368-4.
Martins AD, Moreira AC, Sá R, et al. Biochim Biophys Acta 2015;1852(9): 1824-1832. http://doi.org/10.1016/j.bbadis.2015.06.005.
Martínez-Uña M, López-Mancheño Z, Diéguez C, et al. Int J Mol Sci 2020;21(24): 1-33. http://doi.org/10.3390/ijms21249368.
Amjad S, Baig M, Zahid N, et al. Andrologia 2019;51(1). http://doi.org/10.1111/and.13147.
World Health Organization . WHO Laboratory Manual for the Examination and Processing of Human Semen, 5th ed. WHO Press, 2010.
Bhasin S, Cunningham GR, Hayes FJ, et al. J Clin Endocrinol Metab 2010;95(6): 2536-2559. http://doi.org/10.1210/jc.2009-2354.
WHO. Physical status: use and interpretation of antropometry: report of World Health Commitettee. Geneva, 1995.
Martinez-Una M, Lopez-Mancheno Z, Diegues C, et al. Int J Mol Sci 2020;21(24): 9368. http://doi.org/10.3390/ijms21249368.
Lima TFN, Nackeeran S, Rakitina E, et al. Androg Clin Res Ther 2020;1(1): 94-100. http://doi.org/10.1089/andro.2020.0007.
Agha A, Thompson C. Pituitary 2005;8(3-4): 245-249. http://doi.org/10.1007/s11102-005-3463-4.
Leisegang K, Sengupta P, Agarval A, et al. Andrologia 2021;53(1): e13617. http://doi.org/10.1111/and.13617
ISSN 
ISSN 
